[
]
|
Rule
13d-1(b)
|
[X]
|
Rule
13d-1(c)
|
[
]
|
Rule
13d-1(d)
|
CUSIP
No. 74440J101
|
13G
|
Page
2 of 7
Pages
|
|
1.
|
Names
of Reporting Persons.
I.R.S.
Identification Nos. of above persons (entities only).
RA
Capital Management, LLC
|
||
2.
|
Check
the Appropriate Box if a Member of a Group (See
Instructions)
|
|||
(a)
o
|
||||
(b)
o
|
||||
3.
|
SEC
Use Only
|
|||
4.
|
Citizenship
or Place of
Organization Massachusetts
|
|||
Number
of
Shares
Beneficially
Owned
by
Each
Reporting
Person
With
|
5.
|
Sole
Voting
Power 947,930
|
||
6.
|
Shared
Voting
Power 0
|
|||
7.
|
Sole
Dispositive
Power 947,930
|
|||
8.
|
Shared
Dispositive
Power 0
|
|||
9.
|
Aggregate
Amount Beneficially Owned by Each Reporting Person
947,930
|
|||
10.
|
Check
if the Aggregate Amount in Row (9)
Excludes o Certain
Shares (See Instructions) |
|||
11.
|
Percent
of Class Represented by Amount in Row (9)
5.1%
|
|||
12.
|
Type
of Reporting Person (See Instructions)
IA
|
|||
CUSIP
No. 74440J101
|
13G
|
Page
3 of 7
Pages
|
|
1.
|
Names
of Reporting Persons.
I.R.S.
Identification Nos. of above persons (entities only).
Peter
Kolchinsky
|
||
2.
|
Check
the Appropriate Box if a Member of a Group (See
Instructions)
|
|||
(a)
o
|
||||
(b)
o
|
||||
3.
|
SEC
Use Only
|
|||
4.
|
Citizenship
or Place of
Organization United
States
|
|||
Number
of
Shares
Beneficially
Owned
by
Each
Reporting
Person
With
|
5.
|
Sole
Voting
Power 947,930
|
||
6.
|
Shared
Voting
Power 0
|
|||
7.
|
Sole
Dispositive
Power 947,930
|
|||
8.
|
Shared
Dispositive
Power 0
|
|||
9.
|
Aggregate
Amount Beneficially Owned by Each Reporting Person
947,930
|
|||
10.
|
Check
if the Aggregate Amount in Row (9)
Excludes o Certain
Shares (See Instructions) |
|||
11.
|
Percent
of Class Represented by Amount in Row (9)
5.1%
|
|||
12.
|
Type
of Reporting Person (See Instructions)
IN
|
|||
CUSIP
No. 74440J101
|
13G
|
Page
4 of 7
Pages
|
|
1.
|
Names
of Reporting Persons.
I.R.S.
Identification Nos. of above persons (entities only).
RA
Capital Healthcare Fund, L.P.
|
||
2.
|
Check
the Appropriate Box if a Member of a Group (See
Instructions)
|
|||
(a)
o
|
||||
(b)
o
|
||||
3.
|
SEC
Use Only
|
|||
4.
|
Citizenship
or Place of
Organization Delaware
|
|||
Number
of
Shares
Beneficially
Owned
by
Each
Reporting
Person
With
|
5.
|
Sole
Voting
Power 549,927
|
||
6.
|
Shared
Voting
Power 0
|
|||
7.
|
Sole
Dispositive
Power 549,927
|
|||
8.
|
Shared
Dispositive
Power 0
|
|||
9.
|
Aggregate
Amount Beneficially Owned by Each Reporting Person
549,927
|
|||
10.
|
Check
if the Aggregate Amount in Row (9)
Excludes o
Certain
Shares (See Instructions)
|
|||
11.
|
Percent
of Class Represented by Amount in Row (9)
3.0%
|
|||
12.
|
Type
of Reporting Person (See Instructions)
PN
|
|||
CUSIP
No. 74440J101
|
|
Page 5 of 7
Pages
|
CUSIP
No. 74440J101
|
|
Page 6 of 7
Pages
|
CUSIP
No. 74440J101
|
|
Page 7 of 7
Pages
|
DATE:
RA
CAPITAL HEALTHCARE FUND, L.P.
By:
RA Capital Management, LLC
General
Partner
By: /s/ Peter
Kolchinsky
Peter
Kolchinsky
Manager
RA
CAPITAL MANAGEMENT, LLC
By: /s/ Peter
Kolchinsky
Peter
KolchinskyManager
PETER
KOLCHINSKY
/s/ Peter
Kolchinsky
|
|
RA
CAPITAL HEALTHCARE FUND, L.P.
By:
RA Capital Management, LLC
General
Partner
By: /s/ Peter
Kolchinsky
Peter
Kolchinsky
Manager
RA
CAPITAL MANAGEMENT, LLC
By: /s/ Peter
Kolchinsky
Peter
KolchinskyManager
PETER
KOLCHINSKY
/s/ Peter
Kolchinsky
|
|